

Dr. Alice Stanton
Email:
stantona [at] mit [dot] edu
Address:
500 Main Street
Cambridge, MA 02139
About
Dr. Alice Stanton is an engineer and neuroscientist working at the interface of technology and biological discovery. She aims to invent technologies to accelerate therapeutic development, advance precision medicine approaches, and pioneer new strategies to improve drug delivery. She is an Assistant Professor at Harvard Medical School and Massachusetts General Brigham's Center for Genomic Medicine and Department for Neurology. Alice received her B.S.E. from Princeton University in Chemical Engineering and Engineering Biology and Ph.D. from Stanford University in Bioengineering. She was a Senior Postdoctoral Associate at MIT with Dr. Robert Langer and Dr. Li-Huei Tsai. Alice has been recognized for her work with numerous awards, including with a Rising Star award in Engineering in Health by Johns Hopkins and Columbia University, Rising Star designation in Chemical Engineering by MIT, and Danica Stanimirovic Memorial Award by the International Brain Barriers Society. She was the recipient of the NIA Research and Entrepreneurial Development Immersion Fellowship, NIA Ruth L. Kirschstein NRSA Postdoctoral Fellowship, Kavanaugh Fellowship, and Convergence Scholars Program Fellowship.
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She invented the Neuromatrix brain-mimetic biomaterial enabling enhanced brain modeling to establish the first patient-specific preclinical brain model that includes all the major brain cell types, the miBrain, with integrated BBB, neurovascular units, myelinated neuronal networks, and microglial immune cells in 3D tissue-like architecture. She has developed and characterized the miBrain, demonstrating similarities in response compared to those of the human brain, and harnessed it to probe Alzheimer's Disease-associated mechanisms, revealing a crosstalk between microglia and astrocytes underlying neuronal tau phosphorylation in the context of APOE4. She developed the GelChip microfluidic platform to enable the perfusion through the vessels of the miBrain, forming a miBrain-on-Chip to model delivery to the brain across neurological disease states.
Background





Princeton University
BSE Chemical Engineering, Engineering Biology
Stanford University
PhD Bioengineering
Certificate in Innovation & Entrepreneurship, Stanford Graduate School of Business
Accel Innovation Scholar
d.school Human Centered Design Master's Thesis
Massachusetts Institute of Technology
Senior Postdoctoral Associate
Dr. Robert Langer Laboratory, Dr. Li-Huei Tsai Laboratory
Harvard Medical School, Massachusetts General Brigham
Assistant Professor
Center for Genomic Medicine, Department of Neurology
