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miBrain

Incorporating the 6 Major Brain Cell Types

Each of the major brain cell types differentiated from human
patient-specific iPSC lines.

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Human Brain Tissue Hallmarks

3D integral Immuno-Glial-Neurovascular Units

cell hallmarks_edited.jpg

Capturing Cell-Cell Interactions

Across cell types to include important mechanisms in physiology and disease pathogenesis.

cell interactions.png

Disease Modeling Across Phenotypes with Patient-Specific Human Cells

For example, modeling APOE4 risk for Alzheimer's Disease.

apoe4 modeling.PNG

Enabled by Neuromatrix Hydrogel

Dextran-based biomaterial incorporating brain tissue proteoglycans and basement membrane-mimicking peptides. 

neuromatrix hydrogel.png

Read More:

https://www.biorxiv.org/content/10.1101/2023.08.15.553453v2

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